diff --git a/src/views/business/archive/drugConfig/list.vue b/src/views/business/archive/drugConfig/list.vue
index 58806e0..cc586c7 100644
--- a/src/views/business/archive/drugConfig/list.vue
+++ b/src/views/business/archive/drugConfig/list.vue
@@ -163,7 +163,7 @@ export default {
     },
     gd(row,status) {
       this.operate = 'gd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==9?this.$t('page.business.study.drug.tygd'):this.$t('page.business.study.drug.jjgd'),
@@ -190,7 +190,7 @@ export default {
     },
     jd(row,status) {
       this.operate = 'jd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==5?this.$t('page.business.study.drug.tyjd'):this.$t('page.business.study.drug.jjjd'),
@@ -218,7 +218,7 @@ export default {
 
     jy(row,status) {
       this.operate = 'jy'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.borrowStatus = status
       this.$refs.signRef.show(
         status==10?this.$t('page.business.study.drug.tyjy'):this.$t('page.business.study.drug.jjjy'),
diff --git a/src/views/business/archive/nonTrial/list.vue b/src/views/business/archive/nonTrial/list.vue
index 15581d7..6c54502 100644
--- a/src/views/business/archive/nonTrial/list.vue
+++ b/src/views/business/archive/nonTrial/list.vue
@@ -163,7 +163,7 @@ export default {
     },
     gd(row,status) {
       this.operate = 'gd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==9?this.$t('page.business.study.nonTrial.tygd'):this.$t('page.business.study.nonTrial.jjgd'),
@@ -190,7 +190,7 @@ export default {
     },
     jd(row,status) {
       this.operate = 'jd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==5?this.$t('page.business.study.nonTrial.tyjd'):this.$t('page.business.study.nonTrial.jjjd'),
@@ -218,7 +218,7 @@ export default {
 
     jy(row,status) {
       this.operate = 'jy'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.borrowStatus = status
       this.$refs.signRef.show(
         status==10?this.$t('page.business.study.nonTrial.tyjy'):this.$t('page.business.study.nonTrial.jjjy'),
diff --git a/src/views/business/archive/trial/list.vue b/src/views/business/archive/trial/list.vue
index db9ab42..2ad9c52 100644
--- a/src/views/business/archive/trial/list.vue
+++ b/src/views/business/archive/trial/list.vue
@@ -163,7 +163,7 @@ export default {
     },
     gd(row,status) {
       this.operate = 'gd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==9?this.$t('page.business.study.study.tygd'):this.$t('page.business.study.study.jjgd'),
@@ -190,7 +190,7 @@ export default {
     },
     jd(row,status) {
       this.operate = 'jd'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.status = status
       this.$refs.signRef.show(
         status==5?this.$t('page.business.study.study.tyjd'):this.$t('page.business.study.study.jjjd'),
@@ -218,7 +218,7 @@ export default {
 
     jy(row,status) {
       this.operate = 'jy'
-      this.operateRow = _.clone(row)
+      this.operateRow = _.cloneDeep(row)
       this.operateRow.borrowStatus = status
       this.$refs.signRef.show(
         status==10?this.$t('page.business.study.study.tyjy'):this.$t('page.business.study.study.jjjy'),
diff --git a/src/views/business/stepGroup/list.vue b/src/views/business/stepGroup/list.vue
index c8feb5b..edcb80a 100644
--- a/src/views/business/stepGroup/list.vue
+++ b/src/views/business/stepGroup/list.vue
@@ -189,7 +189,7 @@ export default {
 
     selectStep(row){
       this.stepDialog.visible = true
-      this.stepDialog.data = _.clone(row)
+      this.stepDialog.data = _.cloneDeep(row)
       this.stepDialog.loading = true
       step_list({ pageNum: 1, pageSize:9999}).then(response => {
         this.stepDialog.stepList = response.rows
diff --git a/src/views/business/study/comp/suject.vue b/src/views/business/study/comp/suject.vue
index a8eaf24..3b04eef 100644
--- a/src/views/business/study/comp/suject.vue
+++ b/src/views/business/study/comp/suject.vue
@@ -113,13 +113,15 @@ export default {
           leaderNameEn:'',
         },
 
-        saveList:[]
+        saveList:[],
+        oldList:[]//之前选择的，没修改就不用签名
       },
 
       memberSubject:{},
 
       signType:'',
-      memberList:[]
+      memberList:[],
+      memberOldList:[]//之前选择的，没修改就不用签名
     }
   },
   created() {},
@@ -156,6 +158,8 @@ export default {
       studySubject_getAllListByStudyId({studyId:this.study.id}).then(response => {
         this.infoDialog.list = response.data;
         this.infoDialog.visible = true;
+
+        this.infoDialog.oldList = _.cloneDeep(_.filter(this.infoDialog.list, (o)=> { return o.select }))
       }).finally(()=>{
         this.infoDialog.loading = false;
       });
@@ -171,21 +175,48 @@ export default {
           }
         }
       }
-      this.infoDialog.saveList = postList
+      //判断是否有修改
+      let isModify = false
+      if(postList.length===this.infoDialog.oldList.length){
+        if(postList.length>0){
+          for(let i=0;i<postList.length;i++){
+            let item = postList[i]
+            let find = false
 
-      this.$modal.loading()
-      studySubject_save({
-        studyId:this.study.id,
-        subjectList:this.infoDialog.saveList,
-        sign:{}
-      }).then(() => {
-        this.signType = 'save'
-        this.$refs.subjectSignRef.show(this.$t('page.business.study.study.rybg'),this.$t('page.business.study.study.rybg'))
-      }).catch(() => {
-      }).finally(() => {
-        this.$modal.closeLoading()
-      })
-      
+            for(let j=0;j<this.infoDialog.oldList.length;j++){
+              let old = this.infoDialog.oldList[j]
+              if(old.deptId==item.deptId && old.deptName==item.deptName && old.leader==item.leader && old.leaderName==item.leaderName){
+                find = true
+                break
+              }
+            }
+            if(!find){
+              isModify = true
+              break
+            }
+          }
+        }
+      }else{
+        isModify = true
+      }
+      if(!isModify){
+        this.infoDialog.visible = false
+      }else{
+        this.infoDialog.saveList = postList
+
+        this.$modal.loading()
+        studySubject_save({
+          studyId:this.study.id,
+          subjectList:this.infoDialog.saveList,
+          sign:{}
+        }).then(() => {
+          this.signType = 'save'
+          this.$refs.subjectSignRef.show(this.$t('page.business.study.study.rybg'),this.$t('page.business.study.study.rybg'))
+        }).catch(() => {
+        }).finally(() => {
+          this.$modal.closeLoading()
+        })
+      }
     },
     doSign(val){
       if(this.signType==='save'){
@@ -237,6 +268,7 @@ export default {
             nameEn:response.data[i].userNameEn,
           })
         }
+        this.memberOldList = _.cloneDeep(memberList)
         this.$refs.selectSubjectDeptUserMultipleDialog.show(memberList)
       }).finally(()=>{
       });
@@ -253,19 +285,46 @@ export default {
           })
         }
       }
-      this.memberList = postList
-      studySubjectUser_save({
-        studySubjectId:this.memberSubject.id,
-        subjectUserList:this.memberList,
-        sign:{}
-      }).then(() => {
+      //对比是否有修改
+      let isModify = false
+      if(postList.length===this.memberOldList.length){
+        if(postList.length>0){
+          for(let i=0;i<postList.length;i++){
+            let item = postList[i]
+            let find = false
+
+            for(let j=0;j<this.memberOldList.length;j++){
+              let old = this.memberOldList[j]
+              if(old.id==item.userId && old.name==item.userName){
+                find = true
+                break
+              }
+            }
+            if(!find){
+              isModify = true
+              break
+            }
+          }
+        }
+      }else{
+        isModify = true
+      }
+      if(!isModify){
         this.$refs.selectSubjectDeptUserMultipleDialog.close()
-        this.signType = 'member'
-        this.$refs.subjectSignRef.show(this.$t('page.business.study.study.rybg'),this.$t('page.business.study.study.rybg'))
-      }).catch((e) => {
-      }).finally(() => {
-      })
-      
+      }else{
+        this.memberList = postList
+        studySubjectUser_save({
+          studySubjectId:this.memberSubject.id,
+          subjectUserList:this.memberList,
+          sign:{}
+        }).then(() => {
+          this.$refs.selectSubjectDeptUserMultipleDialog.close()
+          this.signType = 'member'
+          this.$refs.subjectSignRef.show(this.$t('page.business.study.study.rybg'),this.$t('page.business.study.study.rybg'))
+        }).catch((e) => {
+        }).finally(() => {
+        })
+      }
     },
 
     doChangeMember(sign){